They also found that this activation could cause a direct, long-lasting synaptic strengthening -- an enhancement of memory-relevant communication occurring at the junctions between neurons in the hippocampus. This process can mediate improvement of learning and memory. "Some next steps include investigating how big an impact this finding can have on human learning, whether it can eventually lead to an understanding of how patients can develop failing memories, and how to better target effective therapies for these patients," Greene added.