Their main collaborator was Mineo Kondo, a professor and chair of ophthalmology at Mie University Graduate School of Medicine in Tsu, Japan, from whom they found out about a unique population of beagles with night-vision problems. The dogs had been bred by a Japanese pharmaceutical company and displayed behaviours characteristic of night blindness. "In bright light they can walk around and navigate easily, but in darkness they sort of freeze," Aguirre said.